Comparing plasma-depleted platelet concentrates with Regular PCs Produced from CS-3000
- VernacularTitle:血细胞分离机制备的浓缩血小板与洗涤血小板的体外实验对照
- Author:
Chaofu JIANG
;
Xujiang CUI
;
Chuanxi WANG
- Publication Type:Journal Article
- Keywords:
platelet,flow cytometry,CS 3000,GMP 140,GPⅡb/Ⅲa
- From:
Chinese Journal of Blood Transfusion
1988;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Obejective To assess the influence of apheresis and wash on platelet function and morphology.Methods To determine the count,size,distribution,agglutination,aggregation,GMP 140 & GPⅡb/Ⅲa of the platelet from the peripheral blood prior to apheresis and aphersed or washed platelets produced by CS 3000 plus.Results Both apheresed and washed platelets showed decreased PDW,PCT & MPV,but there were no statistical difference between groups.There were no difference in platelet adhesion,aggregation,CD 62p +,CD 41a +,and CD 62p +expression.Both apheresed and washed platelets showed increased CD 41a + expression,but there was no difference between apheresed and washed platelets.Conclusion Flow cytometry measurement of GMP 140 & GPⅡb/Ⅲa may be used for in vitro platelet function assessment.Although apherisis can induce mild platelet activation,platelets apheresed or washed by CS 3000 plus have reliable quality and can be used in a variety of clinical conditions.
