Clinical Characteristics and Outcomes of Pyogenic Liver Abscess in Elderly Korean Patients.
- Author:
Jin Woo WI
1
;
Eun Ae CHO
;
Chung Hwan JUN
;
Seon Young PARK
;
Chang Hwan PARK
;
Young Eun JOO
;
Hyun Soo KIM
;
Sung Kyu CHOI
;
Jong Sun REW
;
Sook In JUNG
Author Information
- Publication Type:Original Article
- Keywords: Pyogenic liver abscess; Aged; Elderly; Prognosis
- MeSH: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anti-Bacterial Agents/therapeutic use; Cardiovascular Diseases/epidemiology/etiology; Child; Drug Resistance, Bacterial; Escherichia coli/isolation & purification; Female; Humans; Incidence; Klebsiella pneumoniae/isolation & purification; Leukocyte Count; Liver Abscess, Pyogenic/*drug therapy/epidemiology/microbiology/*pathology; Male; Middle Aged; Prognosis; Republic of Korea/epidemiology; Retrospective Studies; Sex Factors; Shock, Septic/epidemiology/etiology; Young Adult
- From:The Korean Journal of Gastroenterology 2015;66(1):27-32
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Incidence of pyogenic liver abscess (PLA) has been increasing worldwide, especially in the elderly population. Therefore, the aim of this study is to elucidate the clinical features and outcomes of PLA in elderly patients. METHODS: A total of 602 patients diagnosed with PLA from January 2003 to January 2013 were analyzed retrospectively. The patients were divided according to two age groups; > or =65 years (n=296) and <65 years (n=306). RESULTS: The mean age was 73.59+/-5.98 (range, 65-93) years in the elderly group. Significantly higher incidence of females (52.4% vs. 29.1%, p<0.001), hepatobiliary disease (41.2% vs. 24.8%, p<0.001), hepatobiliary procedure (29.4% vs. 13.7%, p<0.001), underlying malignancy (18.2% vs. 4.6%, p<0.001), culture positivity of resistant organism (20.6% vs. 14.4%, p=0.047), occurrence of complication (19.6% vs. 12.8%, p=0.026), and higher white blood cell (13.44+/-6.56 vs. 12.26+/-5.89, p=0.021), but lower rates of right lobe abscess (67.2% vs. 80.4%, p<0.001), fever (68.6% vs. 79.3%, p=0.003), and lower CRP (16.79+/-9.67 vs. 18.80+/-9.86, p=0.012) was observed in elderly PLA patients, compared to younger patients. Regarding complications, elderly patients had higher incidence of septic shock (8.1% vs. 2.3%, p=0.001) and cardiovascular disease (2% vs. 0%, p=0.014). CONCLUSIONS: More atypical presentations and complications tend to occur in elderly PLA patients compared with younger patients. Clinicians should be aware of these age-related differences in PLA and devise management strategies accordingly.
