A closed-chest pig model of aneurysm
- VernacularTitle:非开胸法建立室壁瘤动物模型的实验研究
- Author:
Li ZHU
;
Kejiang CAO
;
Genshan MA
- Publication Type:Journal Article
- Keywords:
Animal model;
Aneurysm;
Balloon;
Angioplasty
- From:
Chinese Journal of Interventional Cardiology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore and develop a close-chest animal model of acute myocardial infarction (AMI) with left ventricular aneurysm. Methods After anesthesia, 2.0 mm or 2.5 mm angioplasty balloon was positioned in the mid-LAD distal to the first diagnonal branch. The balloon was inflated and occluded the LAD for 150 minutes. ECG and blood pressure were monitored. UCG, cTnI and coronary angiography were also investigated to confirm AMI and the aneurysm. Results Five of seven pigs underwent successful induction of AMI and aneurysm. Two of seven pigs died of ventricular fibrillation. The dynamic changes of ECG and cTnI further confirmed AMI. Regional wall-motion abnormalities were found by two-dimensional echocardiography one hour after AMI and left ventricular aneurysm two weeks later in all pigs. Conclusion A closed-chest pig model of aneurysm after AMI is feasible and has a relatively high induction rate and a low mortality.
