Research on experimental intracerebral hemorrhage with buflomedil hydrochloride injection
- VernacularTitle:赛莱乐治疗实验性脑出血的研究
- Author:
Wenbin WU
;
Changlin HU
;
Yongling ZHENG
- Publication Type:Journal Article
- Keywords:
Intracerebral hemorrhage Buflomedil hydrochloride Rat
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect and safety of buflomedil hydrochloride injection to intra cerebral hemorrhage in rats. Methods We established the experimental intracerebral hemorrhage (ICH) model in rats by stereotactic injecting quantitative collagenase into their left caudate nucleuses.The effects of buflomedil hydrochloride injection on hematoma volume,the score of neurological function deficit signs, as well as histopathological changes were observed. Local capillaries were observed by micrangium perfusion.Results 5 days after buflomedil hydrochloride injection might alleviate Wister rats' neurological function deficit signs, 86% rats from Grade Ⅲ to Grade Ⅰ, 14% rats from Grade Ⅲ to Grade 0( P
