A study of the association between polymorphism of endothelial nitric oxide synthase gene and diabetic nephropathy
- VernacularTitle:内皮细胞型NO合酶基因第7外显子894G→T点突变与糖尿病肾病相关性研究
- Author:
Wenshan LU
;
Yanhu DONG
;
Haiyan WANG
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy Endothelial nitric oxide synthase Gene Polymorphism
- From:
Chinese Journal of Diabetes
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between a 894 G→T mutation at exon 7 of eNOS gene and diabetic nephropathy in type 2 diabetes mellitus of northern chinese Methods A case control study for 228 chinese subjects (including 143 type 2 diabetes mellitus with or without nephropathy and 85 normal control)was performed The number of the 894 G→T mutation alleles were determined by polymerase chain reaction and restriction fragment length polymorphism(PCR RFLP) method combined by DNA sequencing Results The frequency of the T allele and TG genotype at exon 7 were significantly higher in DN+ group than in DN group and control subjects(P
