Effects of TNF alone and Incombination with Antitumor Chemicals on Carcinosarcoma in vitro
- VernacularTitle:肿瘤坏死因子联合化疗药物抗Walker-256肿瘤细胞的研究
- Author:
Hongwei GUO
;
Wenxiang TAN
;
Yi HU
- Publication Type:Journal Article
- Keywords:
tumor necrosis factor;
adriamycin;
flow cytometry;
cell cycle
- From:
Chinese Journal of Cancer Biotherapy
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of rhTNF alone and in combination with antitumor chemicals on Walker-256 cell line in vitro. Methods: the cytotoxic activity in vitro were be examined by MTT method and the flow cytometry(FCM) analysis and alteration of every phase of cell cycle for rhTNF or (and) Adriamycin(ADM) against Walker-256 cell line. Results: rhTNF had a strong activity of antitumor in vitro and good dose-effect relationship(r=0.9811). Compared with negative control group, the effect of rhTNF was significant (P
