Effect of MNNG on Ornithine Decarboxylase Activity in Cells from Adult Schistosoma japonicum
- VernacularTitle:MNNG对日本血吸虫成虫细胞鸟氨酸脱羧酶活性作用的初步研究
- Author:
Hong FAN
;
Min HUANG
;
Qian WANG
;
Manjun LI
- Publication Type:Journal Article
- Keywords:
Schistosoma japonicum, MNNG, ornithine decarboxylase
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the change of ornithine decarboxylase(ODC) activity in cells from adult Schistosoma japonicum after the cells were treated with N\|Methyl\|N\|Nitro\|N\|Nitrosoguanidine (MNNG). Methods The cells were treated with MNNG at a concentration of 3 ?g/ml for 48 hours after the cells being incubated for one week. The cells were then cultured with RPMI\|1640 containing 10% calf serum. ODC activity was detected with spectrophotography. Results ODC activity rose significantly in two to three weeks after the cells were treated with MNNG. Conclusion There was ODC activity in cells from adult S.japonicum and MNNG has an effect to reinforce ODC activity in the cells.
