The role of calpain10 gene polymorphism in the genetic susceptibility to type 2 diabetes in Chinese population
- VernacularTitle:Calpain10基因多态性与中国人2型糖尿病遗传易感性的相关性研究
- Author:
Linong JI
;
Lingxia CHEN
;
Xueyao HAN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus Type 2 Calpain 10 gene Genetics susceptibility
- From:
Chinese Journal of Diabetes
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To test the hypothesis that calpain 10 gene (CAPN 10) contributes to the genetic susceptibility to type 2 diabetes in Chinese population.Methods Case control study. PCR RFLP method was used to determine the distribution of allele and genotype frequencies of SNP43 polymorphism (G/A) and SNP 19 polymorphism (1/2) in the intron 3 of calpain 10 gene in 211 type 2 diabetes patients and 127 normal control subjects. Results The frequency of "G" allele of the SNP43 in type 2 diabetes patients was significantly increased as compared with that in the control subjects (91.9% vs 85.8%, P =0.01). The distribution of allele and genotype frequency of the SNP19 (1/2) polymorphism were equal in diabetes and control groups.In addition, we also observed the association between GG genotype and increased body mass index and waist to hip ratio in the control group.Conclusion This study suggested that calpain 10 gene may contribute to the genetic susceptibility of type 2 diabetes in Chinese population.
