A experimental study on the relationship between transforming growth factor ?_1 and diabetic cardiomyopathy
- VernacularTitle:转化生长因子?_1与糖尿病心肌病关系的实验研究
- Author:
Hong LEI
;
Shixi XIONG
;
Ping CAO
- Publication Type:Journal Article
- Keywords:
Transforming growth factor ? 1 Diabetes mellitus Cardiomyopathy
- From:
Chinese Journal of Diabetes
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of the levels of transforming growth factor ? 1(TGF ? 1),fibronectin(FN),laminin(LN) and collagen content and myocardium ultrastructure in streptozotocin experimental diabetes mellitus rats.To study the role of TGF ? 1 and extracellar matrix(ECM) in diabetic cardiomyopathy episode.Methods Observing myocardium ultrastructure by electron microscope and assaying TGF ? 1,FN,LN by immunohistochemistric,and observing collagen content by VG staining.Results TGF ? 1,FN,LN were expressed more in STZ inroduced diabetic rats than in normal rats.The difference between two groups was significant ( P
