The relationships between CTLA-4 gene exon 1 A/G~(49) polymorphism and type 1diabetes mellitus
- VernacularTitle:CTLA-4基因外显子1A/G~(49)多态性与1型糖尿病的相关性研究
- Author:
Luan WANG
;
Ruixin MA
;
Fei WANG
- Publication Type:Journal Article
- Keywords:
Cytotoxic T lymphocyte associated antigen 4(CTLA 4) Gene polymorphism Type 1 diabetes mellitus Latent autoimmune diabetes in adults(LADA)
- From:
Chinese Journal of Diabetes
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of cytotoxic T lymphocyte associated antigen 4(CTLA 4) gene polymorphism with type 1 diabetes in Chinese Han population.Methods The A/G phenotype at position 49 of the CTLA 4 gene exon 1 was determined by polymerase chain reaction restriction fragment length polymorphism(PCR RFLP)method in 33 typical type 1 diabetes patients,57 latent autoimmune diabetes in adults(LADA) patients and 84 healthy control subjects of Chinese Han.Results The frequency of the CTLA 4/G 49 phenotype was significantly higher in type 1 diabetes patients than in control subjects(55.6% vs 36.9%, respectively, P =0.0005),but there was no significant difference between typical type 1 DM and LADA groups. Neither the presence nor the absence of G 49 allele influenced the occurrence of islet autoantibody(ICA) and glutamate decarboxylase antibody(GADAb).Conclusion The polymorphism of CTLA 4 gene exon1 confers susceptibility to type 1 diabetes. This association is independent of ICA and GADAb.
