The effect and morphology observation of oral administration insulin to NOD mice inducing immune tolerance
- VernacularTitle:NOD鼠口服胰岛素诱导免疫耐受的疗效及形态学观察
- Author:
Ningning HOU
;
Yanhu DONG
- Publication Type:Journal Article
- Keywords:
Immune tolerance Insulin Insulitis
- From:
Chinese Journal of Diabetes
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect on prevention and treatment autoimmune diabetes mellitus in NOD mice by oral administration porcine insulin.Methods One hundred and twenty female NOD mice were divided randomly into insulin group(n=60) and control group(n=60).Beginning from 6 week old, NOD mice were fed porcine insulin 500ul or phosphate buffered saline(PBS) 500ul seperately till 40 week old. At 6 ?12 ?20 ?25 ?30 week old,serum insulin of healthy mice was measured and pancreas were used for histology.Results Oral administration of insulin can marked decreased incidence of diabetes ( P
