The effect of mild hypothermia on neuronal apoptosis and Bcl-2,Bax in the focal cerebral ischemia in rats
- VernacularTitle:亚低温对大鼠局灶性脑缺血神经细胞凋亡及Bcl-2、Bax的影响
- Author:
Zhaohu CHU
;
Wusheng ZHU
;
Jiami WU
- Publication Type:Journal Article
- Keywords:
Mild hypothermia Cerebral ischemia Apoptosis Gene
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of mild hypothermia on neuronal apoptosis and Bcl 2,Bax during cerebral ischemia in middle cerebral artery occlusions(MCAO) in rats.Methods The model of MCAO was set up in rats using the Longa's way,and mild hypothermia was treated for 0.5h,1h,3h. After reperfusion(24h) the rat brains were cut into three sections for TUNEL staining and Bcl 2?Bax protein immunohistochemical staining.Results 1)The numbers of apoptotic cells and Bax cells in the mild hypothermia group(1h, 3h) decreased remarkable as compared with the control group( P
