Dynamic change on GABA transporter mRNA in the hippocampus of rats following PTZ-kindled
- VernacularTitle:戊四氮点燃大鼠海马中GABA转运体动态变化的研究
- Author:
Weiqing ZHANG
;
Zhaofu CHI
;
Wei SHANG
- Publication Type:Journal Article
- Keywords:
GABA transporter Epilepsy Kindled Susceptibility
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of GABA (? aminobutyric acid) transporters in kindled.Methods The rat's GABA model following PTZ kindled was made.The expression of GABA transporter subtype in the hippocampus(GAT 1 mRNA) was measured after PTZ (pentylenetetrazol) kindled seizures by using semiquantitative technique,reverse transcription polymerase chain reaction (RT PCR).Results GAT 1 mRNA was significantly increased in the hippocampus at 0 hour,48 hours,and 1 week after PTZ kindled seizures. Up regulation of expression of GAT 1 mRNA returned to the control levels after 1 month. No changes in the expression of GAT 1 mRNA were observed after 60 days of PTZ kindled seizures.Conclusion The expression of GAT 1 mRNA with up regulation may be associated with the epilepsy susceptibility.
