The expression of interleukin 10 in rat aorta after balloon angioplasty
- VernacularTitle:大鼠主动脉球囊损伤后白细胞介素10的表达
- Author:
Chunfang XIA
;
Yong HUO
;
Naqiong WU
- Publication Type:Journal Article
- Keywords:
Interleukin 10;
Angioplasty;
Inflammation
- From:
Chinese Journal of Interventional Cardiology
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression and distribution of IL 10 in local vessel after balloon injury in rat and study its significance in the response of artery injury Methods RT PCR and Western Blot as well as immunohistochemical method were used to assay the changes of IL 10′s mRNA as well as expression and distribution of protein Results There is no expression of IL 10 in vascular wall of normal rat After Balloon injury, the level of IL 10 mRNA and product of IL 10 was up regulated, and immunohistochemiscal staining showed immunoreactive IL 10 mainly in smooth muscle cells Conclusion IL 10 is expressed in balloon injured aorta and may contribute to the modulation of the local inflammatory response
