The association of PAI-1 gene polymorphism with cerebral infarction and recurrent cerebral infarction
- VernacularTitle:PAI-1基因多态性与脑梗死及再梗死的关系
- Author:
Yingdong ZHANG
;
Qi SUN
;
Yang LIU
- Publication Type:Journal Article
- Keywords:
Cerebral infarction PAI 1 Gene Polymorphism
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of the gene polymorphism of plasminogen activator inhibitor 1 (PAI 1) with the cerebral infarction and recurrent cerebral infarction (RCI). Methods The plasma PAI 1 activity, by means of chromgenic substrate assay, and the sequence polymorphisms of 4G/5G in promotor region and (CA)n dinucleotide repeats in the 4th intron of PAI 1 gene, by amplified fragment length polymorphism assay, were measured in 50 patients with first ever cerebral infarction (FCI), 45 patients with RCI and 60 healthy controls.Results The plasma PAI 1 activities in both FCI patients (1.13?1 1 AU/ml) and RCI (1.13?0.150 AU/ml) were remarkably higher than that in the controls (0.7?0.25 AU/ml) (both P
