Clinical and pathological analysis of Creutzfeldt-Jakob disease
- VernacularTitle:Creutzfeldt-Jakob病的临床及病理分析
- Author:
Dingbo TAO
;
Xiaopei SUN
;
Fan SONG
- Publication Type:Journal Article
- Keywords:
Creutzfeldt Jakob disease Prions Clinical pathology
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study clinical characters and diagnosis of Creutzfeldt Jakob disease (CJD), which will raise the rate of confirmed diagnosis.Methods The clinical manifestation, the results of light microscope and electron microscope in 4 patients with CJD proved by pathological examination were analyzed.Results There was typical clinical manifestation in the 4 patients,neuron degenerative death,gliocyte hyperplasia,no inflammatory change were observed in pathological examination. Degeneration and oncotic of axon in some myelin sheath were found by electron microscope examination.Conclusion CJD is a sporadic desease,no special effective therapy and worse prognosis. Clinical pathological examination is the best method for the diagnosis of CJD.
