Bone metabolic markers in primary osteoporosis typeⅡ
- VernacularTitle:骨代谢生化指标与老年男性骨质疏松症关系的探讨
- Author:
Guiping AI
;
Ling LUO
;
Deqin GAO
- Publication Type:Journal Article
- Keywords:
Osteoporosis;
Bone absorption;
Osteogenesis
- From:
Chinese Journal of Laboratory Medicine
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between age and biochemical markers of bone absorption and bone formation in old men. Methods Urinary deoxypyridinoline crosslinks (Dpd),calcium (Ca),serum bone g1aprotein (BGP),procollagen I C terminal peptides (PICP) and testosterone (Tes) were determined by ELISA. Urinary hydroxyproline (Hyp) was tested by HPLC,and bone specific alkaline phosphatase (BALP) was assayed by electrophoresis. The data from 210 old man were compared with those of postmenopausal women and young men. Results As the age increased in old men, the levels of bone absorption markers increased (Dpd:12.6%,Hyp:23.5%), and bone formation markers decreased (BGP:3.1%,PICP:45.9%).The average level of Dpd in old men was (4.53?1.34) nmol/mmolCre, lower than that of postmenopausal women [(7.90?3.27) nmol/mmolCre] and young men [(6.78?3.31) mol/mmolCre], t test P
