An investigation on the relationship between sulfonylurea receptor 1 gene intron 24-3t/c polymorphism and blood lipids in Chinese population
- VernacularTitle:磺脲受体1基因多态性与血脂的相关性研究
- Author:
Yan FENG
;
Qiongfang LI
;
Changzhong CHEN
- Publication Type:Journal Article
- Keywords:
Sulfonylurea receptor 1 Gene Blood lipid
- From:
Chinese Journal of Diabetes
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Obeject To study the association of sulfonylurea receptor (SUR) 1 gene and blood lipids level.Method We investigated the SUR1 gene intron 24 3t/c polymorphism by polymerase chain reaction (PCR) and appropriate restriction enzyme (PCR RFLP) in 132 couples of type 2 diabetic case control and 282 type 2 diabetic pedigrees. The statistical methods were t test, multiple line regression and family based association test (FBAT).Result In the control group, the level of total cholesterol (TC), low density lipoprotein (LDL) and Apo B were higher in the cc genotype than that in the tt and the tc genotype. FBAT showed that sulfonylurea receptor 1 gene intron 24 3t/c polymorphism was significantly associated with TC, ApoB and BMI.Conclusion Sulfonylurea receptor 1 gene intron 24 3t/c polymorphism is associated with blood lipid level in north Chinese population.
