Therapeutic role on monoclonal antibody of alkaline phosphatase to vasogenic cerebral edema in rats
- VernacularTitle:碱性磷酸酶单克隆抗体对大鼠血管源性脑水肿的治疗作用
- Author:
Xinyu WANG
;
Bingxun LU
- Publication Type:Journal Article
- Keywords:
Vasogenic cerebral edema Monoclonal antibody of alkaline phosphatase Therapy
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic role on monoclonal antibody of alkaline phosphatase(AAP) to vasogenic cerebral edema in rats(VCE).Methods 60 Wistar rats were randomly divided into 3 groups:normal group,VCE group and AAP group.VCE animal model was made by injecting AAP.Brain water content of gray and white matter were measured by Moistrue Analyzer respectively.The permeability of the blood brain barrier (BBB) was determined by Evan's blue(EB) extravasation.Results The brain water content of gray and white matter in AAP group was reduced markedly,so the permeability of BBB was reduced(P0.05). Conclusion AAP can treat VCE well. Morbidity mechanism of VCE is related to the activity of alkaline phosphatase.
