Effect of methotrexate (MTX) on daily dose in treating psoriasis at the Dermatological Department of the Army Central Hospital
- Author:
Dang Van Em
- Publication Type:Journal Article
- Keywords:
Psoriasis
- MeSH:
Psoriasis;
Therapeutics;
Methotrexate
- From:Journal of Practical Medicine
2005;0(6):21-23
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
A prospective study was conducted on 33 psoriasis patients treated with methotrexate (MTX) 0.1mg/kg in continuous 5 days at the Dermatological Department of the Army Central hospital from 2000-2004. Results: MTX had high effect in treatment of usual psoriasis (very good: 24.24%; good: 21.21%; relatively good: 45.45%; medium 9.10%); it had early effect (at the first round) and had effect on all kinds of psoriasis: usual type (with the severe level, PASI reduced 64.76%; average 70.99%; light: 94.86%) DDTT type (PASI reduced 73.63%). After methotrexate therapy, 45.45% of patients had a increased rate of SGOT, 39.39% had a increased rate of SGPT; the number of white blood cells decreased in 9.1% of patients, and red blood cells and platelet decreased in 3% of patients . Additionally, the treatment also caused some other symptoms such as fatigue in 10/33 patients (30.3%), anorexia in 13/33 patients (39.40%). The researcher suggested: do not use MTX at daily dose to treat psoriasis.
