The study of AT_1 A/C gene polymorphism in type 2 diabetes patients
- VernacularTitle:2型糖尿病合并冠心病AT_1A/C多态性研究
- Author:
Ling GAO
;
Huifeng YE
;
Peizhen GAN
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes Angiotensin Receptor Gene polymorphism
- From:
Chinese Journal of Diabetes
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine whether the AT, All66C gene polymorphism is associated with CHD in type 2 diabetes patients. Methods Investigating the allele frequency and the genotype distribution of the AT1 All66C gene in the group of normal control (n= 73),simple diabetes (n= 80),diabetic CHD (n=43) by means of PCR-RFLP. Results The group of diabetic CHD had a significant higher frequency of C allele of the AT1 All66C gene than normal control (X2 = 6. 02,P＜0. 05) and diabetes (X2= 5. 71,P＜0. 05). Conclusion The result indicated that there was an association between the 1166C allele of the AT1 gene polymorphism and CHD in type 2 diabetes patients.
