Local intraluminal infusion of PLGA dexamethasone nanoparticles for prevention of restenosis after balloon angioplasty
- VernacularTitle:纳米粒子携带地塞米松局部腔内注射预防球囊损伤后再狭窄的实验研究
- Author:
Yong ZENG
;
Wenlin ZHU
;
Zhenfeng ZHU
- Publication Type:Journal Article
- Keywords:
Nanoparticles;
Local drug delivery;
Restenosis;
Angioplasty
- From:
Chinese Journal of Interventional Cardiology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the tissue compatibility of PLGA Nanoparticles and the effect of local intraluminal infusion of dexamethasone nanoparticles on restenosis after balloon angioplasty Methods PLGA nanoparticles were intraluminally administered after balloon injury in the rabbit iliac model Retention at different time points and biocompatibility of nanoparticles were evaluated Dexamethasone nanoparticles were also used in the same model to observe the effects on restenosis Results The PLGA nanoparticles apperaed to be fully biocompatible In the dexamethasone nanoparticles study, dexamethasone was presented in the treated segment for up to 14 days There is a significant reduction in intima/media ratio in treated animals compared with control Conclusion PLGA nanoparticles have good tissue compatibility Local administration of dexamethasone nanoparticles can retentate in vessel wall for more than 14 days and significantly decreased neointimal formation
