Dosimetry of endovascular irradiation using beta emitters in the prevention of restenosis
- VernacularTitle:?-核素在预防血管成形术后再狭窄中的剂量学
- Author:
Yingmao CHEN
;
Jiahe TIAN
;
Shuwen ZHANG
- Publication Type:Journal Article
- Keywords:
Brachytherapy;
Dosimetry;
Restenosis;
Beta Emitter
- From:
Chinese Journal of Interventional Cardiology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To give a dose reference to the researcher who study prevention of restenosis using endovascular brachytherapy Methods The dose distributions around a 3 mm diam by 20 mm long balloon filled with 90 Y , 32 P and 186 Re separately have been calculated by a computer program based on a dose point kernel Results The peak value of the absorbed dose is found inside the balloon, the inflexion of the dose curve at the endothelial surface of the vessel In the vessel tissue the dose decreases with distance in an approximately exponential manner The lower the nuclide energy is, the faster the dose falls with distance, and the longer the region of uniform dose distribution along vessel wall is The dose rate at the surface of the vessel wall is approximately 74, 71, and 45 mGy/min per mCi/ml, with the dose rate decreasing to 53%, 48% and 28% at 0 5 mm for 90 Y , 32 P and 186 Re separately Conclusion The fast falling of the dose in an approximately exponential manner in the vessel tissue makes for focusing ? radionuclide energy to the vessel wall target and reducing the injury of the normal tissue around the vessel, and especially 186 Re with lower energy has a more obvious advantage in this aspect
