The expression of chemokine factor in the muscular tissue of simple polymyositis
- VernacularTitle:单纯多发性肌炎肌肉组织中趋化因子的表达
- Author:
Zhiling HUANG
;
Bo XIAO
;
Guangjie XIE
- Publication Type:Journal Article
- Keywords:
Simple polymyositis Chemokine Immunohistochemistry
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the protein expression of chemotactic monocyte chemotactic protein 1 (MCP 1), macrophage inflammatory protein 1 alpha (MIP 1alpha) and regulated on activation normal T cell expression secretion (RANTES) in the affected muscle of simple polymyositis (SPM), and analysed the relationship between the amount of these proteins and the stage, severity of SPM.Methods Immuohistochemical LAB technique was used to detect the expression of these chemotactic factor protein in SPM affected muscle specimens.The expression levels of these chemotactic factors were determined by Image Analyzer system.Results The expressions of these chemotactic factors protein in SPM were showed in SPM. The expression levels of MCP 1 increased remarkably in the chronic SPM group and the severer one (P0 05).Conclusion MCP 1 not only could play an important role in the chronic SPM,but also related to the severity of the disease,it might be as an index on the development and deterioration of the di sease;MIP 1alpha might contribute to the continuous development of the disease. RANTES might embody its role as a ubiquitous response to inflammation during the onset of SPM.
