The effect of long term intelligence on NGF to the newborn rat with hypoxic-ischemic brain damage
- VernacularTitle:神经生长因子对新生大鼠缺氧/缺血性脑损伤远期智能的影响
- Author:
Laishuan WANG
;
Changlian ZHU
;
Xiuyong CHENG
- Publication Type:Journal Article
- Keywords:
Nerve growth factor Intelligence Hypoxia/Ischemia
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of long term intelligence on NGF to the newborn rats with hypoxic ischemic brain damage (HIBD).Methods The model of newborn rat hypoxic ischemic brain damage(HIBD) was set,0.01mg/10g dosage NGF and 0.03mg/10g dosage NGF were administered to the rat abdominal cavity respectively. With maze test, the change of learning memory abilities of long term in the rats were observed, the concentration of monoamine neurotransmitters in the brain tissue were determined by high performance liquid chromatography electrochemical detector.Results The function of learning and memory was better in NGF group(small, large amount group)than in the control group, the frequency was lower remarkably than the control group( P
