Relationship between reactive astrogliosis and delayed neuronal ischemic tolerance by preconditioning ischemia in hippocampal CA_1 region
- VernacularTitle:缺血预处理后海马CA_1区反应性星形胶质细胞增生与迟发性神经元缺血耐受性的关系
- Author:
Changsheng WANG
;
Zhenglu HUO
;
Ruihe YANG
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia Neuroglia Ischemic tolerance
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between reactive astrogliosis and delayed neuronal ischemic tolerance by preconditioning ischemia in gerbil hippocampal CA 1 region.Methods All gerbils were divided randomly into sham operation group,cerebral ischemia group and preconditioning ischemia group and preconditioning ischemia plus subsequent ischemia group. Transient forebrain ischemia model was induced by bilateral carotid occlution in gerbils. Immunohistochemistry for cell specific markers (glial fibrillary acidic protein(GFAP)was used to identify astrocyte.Results The numbers of GFAP positive astrocyte in hippocampal CA 1 region increased slightly at 1~7days following preconditioning ischemia, but increased significantly at 28 days after preconditioning ischemia ( P
