Anticonvulsant activity of allopregnanolone against pentylenetetrazol- induced seizures in rodents
- Author:
Yingqing LU
;
Rong YU
- Publication Type:Journal Article
- Keywords:
allopregnanolone;
pentylenetetrazol;
seizure;
ED50
- From:
Chinese Journal of Tissue Engineering Research
2001;05(1):155,157-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the protective effects of allopregnanolone against pentylenetetrazol- induced seizures. Methods The protective effects of allopregnanolone against pentylenetetrazol- induced seizures were studied in C57 mice and SD rats 15 minutes after vehicle or drug intraperitoneal (ip) administration. Results The pretreatment with the allopregnanolone produced a dose- dependent protective effect against pentylenetetrazol- induced seizures. The potencies (ED50 values) were 4.7 mg/kg and 9.8 mg/kg for mice and rats, respectively. Conclusion Allopregnanolone has anticonvulsant activity against pentylenetetrazol- induced seizures in rodents.
