A study on the relationship between TNF-? and diabetic retinopathy in rat
- VernacularTitle:TNF-?值与糖尿病大鼠视网膜病变关系
- Author:
Hongyu KUANG
;
Dan LIU
;
Wei ZOU
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor-? Diabetic retinopathy Animal laboratory
- From:
Chinese Journal of Diabetes
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between serum level of TNF-? and morphologic changes as well as related factors in 3 and 6 months of diabetic retinopathy rats. Methods This research successfully duplicated a model of insulin dependent diabetes mellitus in rats and carried out morphologic observation of retina of diabetic rat when the disease lasted for 3 and 6 months. The serum level of TNF-? by ELISA together with related factors, such as blood glucose (BG)by oxidase method、glucosylated hemoglobin (GHbAlc) 、serum insulin (Ins) and c-peptide (C-P) by RIA were studied. Results In same duration,the levels of TNF-?、BG、GHbAlC in model groups were significantly higher than therapy groups (P
