L-arginine attenuates proten expression of related cell cycle regulatory factors in rats after balloon injury
- VernacularTitle:L-精氨酸抑制球囊损伤后大鼠血管内膜增生的机制研究
- Author:
Xiaomin NIE
;
Ruiyun LIU
;
Zhenwen HUANG
- Publication Type:Journal Article
- Keywords:
L-arginine;
Balloon injury;
Cell cycle regulatory
- From:
Chinese Journal of Interventional Cardiology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine whether the anti-proliferation effect of L-arginine is due to inhibiting the expression of cyclin dependent kinase-2 (CDK2)、 CyclinE and proliferation cell nuclear antigen (PCNA) in blood vessel after balloon injury. Methods Rats were randomized into three groups: Group S (sham operation group), Group C (balloon injury control group) and Group L (balloon injury + L-arginine group). After 14 days, blood samples were collected for biochemical studies, and the thoracic aortas were harvested for immunohistochemistry. The expression of CDK2、 CyclinE and PCNA were measured by means of computer image analayzer. Results The levels of plasma nitric oxide (NO) in group C were significantly lower than those in group S. Compared with group C, the levels of plasma NO increased (P
