The antihypertensive effect of marine sulfated polysaccharide AHD and its related mechanisms of action
- VernacularTitle:海洋硫酸多糖AHD的降压作用及其机制的初步探讨
- Author:
Lichun WANG
;
Metyu GENG
;
Xinyan QU
;
Huashi GUAN
- Publication Type:Journal Article
- Keywords:
Renovascular hypertensive rats (RHR);
Marine sulfated polysaccharide AHD;
Hypotensive effect,Nitric oxide (NO);
Angiotensin (Ang Ⅱ );
Endothelin(ET)
- From:
Chinese Journal of Marine Drugs
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The antihypertensive effect of marine sulfated polysaccharide AHD and its underlying mechanisms were studied in renovascular hypertensive rats (RHR) [two-kidney one clip,Goldblatt(2-K 1C)J. AHD were given orally at doses of 12.5, 25,50mg?kg～-1 once a day for five weeks,simultaneously wity the initiation of the establishment of renovascular hypertensive model. Serum nitric oxide(NO) was determined with NO kit,and plasma Angiotensin E (Ang Ⅱ ) and Eneothelin (ET) Were measured by radioimmumoassays. The results indicated that AHD decreased arteial blood pressure in a dose-dependent manner. Moreover, nitric oxide (NO) contents in serum were dose-dependently elevated,accompanied by dramatic reduction in Ang Ⅱ and ET contents. These findings suggested that AHD exerted its hypotensive activity by enhancing tye release of NO,followed by reduction in production of boty ANG Ⅱ and ET in vivo.
