Effects of chitosan on hepatic lipids and mitochondria in fatty liver rats
- VernacularTitle:壳聚糖对脂肪肝大鼠脂含量及线粒体功能的影响
- Author:
Xiaohong QI
;
Li JIANG
;
Xiaoyu LI
;
Yuehua LI
;
Cuizhen WU
- Publication Type:Journal Article
- Keywords:
chitosan;
fatty liver;
TG;
TC;
mitochondria;
lipid peroxidation membrane lipid fluity.
- From:
Chinese Journal of Marine Drugs
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim: To study the effects of chitosan on hepatic lipids in fatty liver rats. Methods: The rats given a low does of carbon tetrachloride (CCl4) and fed a high-fat diet were treated with chitosan in different doses. Results: When rats were treated with mid dose of chitosan (4mg? g~-1?d~-1), the contents of triglycerde (TG). total cholesterol (TC) in liver decreased significantly, the level of mitochondria malonal-dialdehyde (MDA) was markedly attenuated and the mitochondria membrane fluidity was restored, which compared with model group. Conclusion: Chitosan may decrease the hepatic lipids by reduced the lipid peroxida- tion and restored mitochondria membrane fluidity to improve the mitochondrial beta-oxida- tion.
