Influence of plasma lipid level on the accumulation of glomerular extracellular matrix in OLETF diabetic rats
- VernacularTitle:血脂变化对OLETF糖尿病大鼠肾小球细胞外基质成分含量的影响
- Author:
Yu CHEN
;
Xiaohui GUO
;
Dingqiong PEN
- Publication Type:Journal Article
- Keywords:
Glomerular extracellular matrix (ECM) OLETF rats Type 2 diabetes mellitus Hyperlipidemia Fenofibrate
- From:Chinese Journal of Diabetes
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of changes in plasma lipid levels on the accumulation of glomerular extracellular matrix in type 2 diabetic rats.Methods Rats were divided into three groups,namely,normal control,diabetes mellitus treated with Fenofibrate,which was gastrically administrated in the dose of 20mg?kg -1 ?d -1 for 22 weeks.A quantitative analysis of the components of glomerular extracellular matrix (ECM) were performed with immunoperoxide (ABC) method and the computer imagine analysis system.Results The result showed that diabetic rats had significantly higher plasma lipid levels and accumulation of ECM including collagen Ⅳ,laminine and fibronectin than the normal control ( P
