The Correlation between the Expression of Vascular Endothelial Growth Factor and Angiogenesis in Human Gastric Xenografted Carcinoma
- VernacularTitle:血管内皮生长因子的表达和血管生成与人胃癌移植瘤生长的关系
- Author:
Duhu LIU
;
Xueyong ZHANG
;
Yuxin HUANG
;
Daiming FAN
- Publication Type:Journal Article
- Keywords:
vascular endothelial growth factor;
angiogenesis;
solid tumor
- From:
Chinese Journal of Cancer Biotherapy
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the correlation between the expression of vascular endothelial growth factor(VEGF) and angiogenesis in tumor. Methods: VEGF 165 sense and antisense gene recombinants were introduced into human gastric cancer cells, respectively. Then the growth of transfected cells in nude mice and the microvascular density and histological change were examined. Results: The growth rate of tumor in nude mice inoculated with sense VEGF cells was markedly higher than that in nude mice inoculated with antisense-VEGF cells. In histological examination, the microvascular density in tumor caused by sense-VEGF cells was greatly higher than that in tumor caused by antisense VEGF cells. Conclusion: As starting angiogenesis, VEGF might promote the growth of tumor, and the inhibition of VEGF production might prevent solid tumor from growing.
