Effect of quercetin on expression of TGF-?_1 in kidney of streptozotocin-induced diabetic rats
- VernacularTitle:槲皮素对糖尿病大鼠肾脏转化生长因子-?_1(TGF-?_1)表达的影响
- Author:
Xiangjin XU
;
Yusui WU
;
Xiugao FENG
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy Quercetin Transforming growth factor ? 1
- From:
Chinese Journal of Diabetes
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of Quercetin treatment on diabetic nephropathy.Methods Quercetin 100mg/(kg?d) was given to diabetic rats.Urinary albumin excretion was measured by radioimmunoassay.The expression of TGF ? 1 protein and TGF ? 1 mRNA in renal cortex of diabetic rats were determined by immunohistochemical staining and RT PCR analysis.Results Quercetin treatment decreased urinary albumin excretion in diabetic rats.TGF ? 1 immunohistochemical staining and TGF ? 1 mRNA levels in Quercetion treated group was significantly decreased than untreated DM group ( P
