Direction effect of drug sensitivity test of bladder cancer and the individual choice of chemotherapy

VernacularTitle:膀胱肿瘤化疗药物敏感性试验对个体化治疗的指导作用
Author: Zhen CHEN ; Jinxian PU ; Weiguo CHEN ; Zinong TIAN
Publication Type:Journal Article
Keywords: Urinary bladder neoplasms; Antineoplastic combined chemotherapy protocols; Drug screening assays,antitumor
From: Cancer Research and Clinic 2009;21(3):178-179,182
CountryChina
Language:Chinese
Abstract: Objective To evaluate the direction effect of drug sensitivity test of bladder cancer and the individual choice of chemotherapy. Methods MTT was used to determine chemotherapy and all 34 patients were followed up for 6-43 months. 48 cases were based on the experience of doctors control. Results The sensitive cases were ADM19, THP16, MMC20, OPT30. The sensitive rate was epi-ADM 59.4 %, THP 47.6 %, MMC 41.2 %, OPT 88.2 %. The recurrence rate was 8.82 % in drug sensitivity group, 31.2 % in control group, the result of experiment group was perfect to the control.group. Conclusion The difference of the individual chemotherapy sensitivity is significant. The drug sensitivity test can improve the therapeutic effect of bladder cancer.