Plasma concentraion of rifampicin in smear-positive pulmonary tuberculosis patients using fixed-dose combination drugs
- Author:
Hoang Thi Kim Huyen
- Publication Type:Journal Article
- Keywords:
rifampicin
- MeSH:
Rifampin;
Tuberculosis, Pulmonary;
Pharmaceutical Preparations;
Plasma
- From:Journal of Practical Medicine
2005;505(3):46-49
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Setting: Although rifampicin is an essential anti-tuberculosis drugs, but there is variable inter-individual on plasma rifampicin concentration. In addition, poor bioavailability is concern problem when using fixed-dose combination drugs in treatment of tuberculosis. Objective: To investigate possible variations in plasma rifampicin concentration in tuberculosis patients using fixed dose combination drugs in National Tuberculosis Programme. Design: 2-hour plasma rifampicin concentration was measured by HPLC method among 50 smear-positive pulmonary tuberculosis patients. Results: Plasma rifampicin concentrations were generally low: 86% of patients had 2-hour plasma rifampicin concentration below 80g/ml, and 40% of patients had plasma concentration below 40g/ml. Although treatment at the same dose levels, there is high variable between individual patients in plasma rifampicin concentration. Rifampicin concentration was higher in female,> 60 years old, < 40 kg body weight. There is no difference in mean plasma concentration between new tuberculosis patients and re-treatment tuberculosis patients groups. Conclusion: The unexpected low plasma concentration of rifampicin in this setting are most likely due to poor bioavailability in fixed dose combination drugs. A study on bioavailability of rifampicin from fixed dose combination using in National Tuberculosis Programme is necessary.
