Predictive value of combined determination of ICA、64KDAb and IAA in the first-degree relatives of type Ⅰ diabetics
- VernacularTitle:ICA、64KDAb、IAA联合检测在1型糖尿病一级亲属中的预测价值
- Author:
Weihua WU
;
Jinchao ZHANG
;
Lixin LI
- Publication Type:Journal Article
- Keywords:
Lslet cell antibody insulin auto-antibody Type I diabetes
- From:
Chinese Journal of Diabetes
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the predictive value of islet cell antibody (ICA),64KD protein antibody(64KDAb) and insulin auto-antibody (IAA) in the first-degree relatives of type 1 diabetics. Methods The determination of islet autoantibody distribution in type 1 diabetes patients,first-degree relatives without diabetes and normal individuals was made. Results The results revealed that ICA and 64KDAb positive rate in type I diabetes patients and their first-degree relatives was significantly higher than normal individuals. The positive rate of 64KDAb is higher than that of ICA and IAA. Conclusion These results suggest that 64KDAb's sensitivity is higher than ICA and IAA's,so 64KDAb is more valuable as the marker of predicting type 1 diabetes. The combined determination of ICA, 64KDAb and IAA might improve the value for predicting diabetes.
