Influence of metformin on the protein expression of IRS-1 in target tissues or OLETF rats
- VernacularTitle:二甲双胍对OLETF大鼠靶组织内胰岛素受体底物-1蛋白表达水平的影响
- Author:
Dingqiong PENG
;
Yan GAO
;
Yu CHEN
- Publication Type:Journal Article
- Keywords:
Metformin Insulin receptor substrate-1 Type 2 diabetes mellitus
- From:
Chinese Journal of Diabetes
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the molecular mechanism of metformin. Methods The changes of protein expression of IRS-1 in liver, skeletal muscle and adipose tissues after treatment with metformin for OLETF rats, a model of spontaneous type 2 diabetes mellitus, were measured by Western blot analysis, and compared with those before treatment. Results 22 weeks after the treatment with metformin, the protein expression of IRS-1 was significantly increased in liver (P0. 05) ;and the protein expression of IRS-1 in adipose tissue was significantly decreased (P
