Oligodendrocyte selective vulnerability in gray matter area and the effect of subhypothermia after transient forebrain ischemia in gerbils
- VernacularTitle:沙土鼠短暂性脑缺血后灰质区少突胶质细胞选择性易损性及亚低温的影响
- Author:
Changsheng WANG
;
Zhenglu HUO
;
Ruihe YANG
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia Oligodendrocyte Subhypothermia Demyelination`
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore oligodendrocyte selective vulnerability in gray matter area and the effect of subhypothermia after transient forebrain ischemia in gerbils.Methods The gerbils model of forebrain ischemia was induced by 15 min bilateral carotid occlusion.All gerbils were divided randomly into sham operation group,ischemic reperfusion group and subhypothermia treatment group (32.5?0.5℃).Immunohistochemistry for cell specific antigens (transferrin,TF) was used to identify oligodendrocyte.Results The density of TF positive oligodendrocyte in the cortex at 1～2 days reperfusion following ischemia decreased remarkably (P
