The effects of large dose methylprednisolone on cerebral damage of Wistar rats after focal ischemic reperfusion
- VernacularTitle:大剂量甲基强的松龙对大鼠局灶性缺血再灌注脑损伤的影响
- Author:
Lihong ZHOU
;
Sixin WANG
;
Fangfang WANG
- Publication Type:Journal Article
- Keywords:
Methylprednisolone Cerebral ischemia Cerebral edema Macrophage
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the mechanism of large dose methylprednisolone(MP) on cerebral protection of rats after focal ischemic reperfusion.Methods Using the Wistar rat models of focal cerebral ischemic reperfusion,we observed the effects of large dose MP before and after ischemia on the volume of middle cerebral after infarction and the change of cerebral water content,meanwhile the pathological change of brain tissue was observed.Results Compared with the control group, the volume of middle cerebral after infarction in MD treatment group was remarkably reduced before and after ischemia (P 0 05 ). From the control group but not the MP treatment group, we found cerebral infiltration of macrophages from the histopathology of rat brain tissues.Conclusion Large dose MP might improve ischemic brain injury,the mechanism related to reducing volume of cerebral infarction and inhibited the infiltration of macrophages in the rat brain tissues.
