The relationship between the levels of serum oxide and antioxide in patients with Wilson disease and its visceral injury
- VernacularTitle:Wilson病患者血清氧化物和抗氧化物水平与内脏损伤的关系
- Author:
Zunsheng ZHANG
;
Renmin YANG
- Publication Type:Journal Article
- Keywords:
Wilson disease Free radicals PathogenesiX
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the levels of serum oxide and antioxide in patients with Wilson disease (WD) and its visceral injury.Methods We determined the serum levels of MDA,GSH PX,GSH and VitE in 29 patients with WD and 21 normal controls by the method of reversephase high performance liquid chromatography (RP HPLC) and the chemo colorimetric method.Results The serum levels of MDA in all patients with WD were significantly higher than those of controls( P 0 05 ).Conclusion There was metabolism disorder of free radicals (FRs) in the serum of patients with WD.As compared with normal controls the serum levels of oxides increased and the levels of antioxides decreased in patients with WD,it might be one of important factors for the patients with visce ral injury.
