Effect of synthetic corticotropin with vitamin B_6 on intractable epilepsy of children
- VernacularTitle:合成促皮质素及维生素B_6联合治疗婴幼儿癫痫
- Author:
Yanping WANG
;
Weiping LIAO
;
Ying PAN
- Publication Type:Journal Article
- Keywords:
Synthetic corticotropin Vitamin B 6 Infantile spasms syndrome Intractable epile
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of synthetic corticotropin with vitamin B 6 on intractable epilepsy of children.Methods 20 patients (3 months to 4 years old) among which 9 children with infantile spasms and 11 children with intractable epilepsy were injected with vitamin B 6 (50～100 mg/d) for 10 days,then treated with cortrosyn 0 015~0 025 mg/Kg?d by the interval mothod of lengthening dosage,total course of treatment was about 2 months,seizure,EEG and some blood biochemical tests were observed in all patients before and after the course of treatment.Results The seizure of 14 patient children stopped after the treatment,seizure frequency was decreased in 5 patients (from 15 to 40 times/week decreasing to 3 to 14 times/week respectively),1 patient with intractable epilepsy was stopped treating because of side effect.The general clinical condition and EEG were also improved.The blood biochemical tests about liver and kidney were normal during treatment,hypokaliemia,hypocalcemia and slight dropsy were appeared in some patients.Conclusion Cortrosyn with vitamin B 6 is effective for infantile spasms and intractable epilepsy in children of low age.
