in vivo and in vitro Anti-Tumor Effeciency of B16 Melanoma HSP-Antigen Peptide Complex (HAC)
- VernacularTitle:黑色素瘤B16细胞热休克蛋白-抗原肽复合物的体内外抑瘤效应
- Author:
Ying YANG
;
Xiujuan LI
;
Zuyue SUN
;
Shouliang GONG
;
Xiuyi LI
- Publication Type:Journal Article
- Keywords:
HSP-antigen peptide complex (HAC);
cytotoxic T lymphocyte;
inhibiting tumor activity
- From:
Chinese Journal of Cancer Biotherapy
1995;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the anti-tumor efficiency of B16 melanoma HACs in vivo and in vitro.Methods: Tris-HCI extract and Sephacryl S-200 gel filtration were applied to prepare B16 HACs, and the cytolokicity of specific CTL induced by HACs was tested. Results: The 41, 47 and 53 tube HACs obtained by gel filtration could decrease the tumor incidences, delay the time of tumor development and decrease the mortalitites of mice.Conclusion:60 ~ 97 kD HACs from B16 melanoma cytosol have the activites of inhibiting tumor and could be used in effective anti-tumor therapy.
