The Role of Macrophages in the Induction of Antitumor Immune Responses of the Mice Immunized with MIF Gene-Modified Tumor Vaccine
- VernacularTitle:巨噬细胞在MIF基因修饰瘤苗诱导小鼠抗肿瘤免疫中的作用
- Author:
Yanjun LIU
;
Yeping TIAN
;
Xuetao CAO
- Publication Type:Journal Article
- Keywords:
macrophage migration inhibitory factor;
macrophage;
tumor vaccine;
gene therapy;
immunotherapy
- From:
Chinese Journal of Cancer Biotherapy
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the mechanisms involved in the induction of antitumor immune responses by MIF gene- modified tumor vaccine. Methods: The changes of the number and the functions of macrophages from the force immunized with MIF gene-modified FBI3 tumor vaccine were analysed.Results: The number,the expression of surface molecules associated with immune responses, the secretion of TNF-?and NO, the phagocytosis, the cytototicity and the antigen presenting activity of peritoneal macrophages from the mice immunized with MIF gene-modified tumor vaccine were all enhanced. Conclusion: The functional enhancement of macrophages is related to MIF secreted by MIF gene-modified tumor vaccine in vivo and the activation of macrophage may play an important role in the antitumor immune responses induced by MIF gene-modified tumor vaccine.
