IL-12 Synergizes B7-1 Enhance the Antitumor Immunity in Experimental Mice
- VernacularTitle:IL-12协同B7-1增强实验小鼠的抗肿瘤免疫
- Author:
Zhihua WANG
;
Xixiong KANG
;
Tani KENZABURO
;
Sumimoto HIDETOSHI
;
Nakazaki YAKON
;
Asano SHIGETAKA
- Publication Type:Journal Article
- Keywords:
IL-12;
B7-1;
GM-CSF;
cancer vaccine;
gene therapy
- From:
Chinese Journal of Cancer Biotherapy
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the vaccine potency of gene-modified tumor cells, we have constructed IL-12, H7-1 and GM-CSF express vector using retrovirus. Methods: It was transfected into EL-4 thymic lylmphoma cells respectively and the effect of gene transduction on anti-tumor immunity were investigated. Results: The tumorigenicity of EL-4/IL-12 transfectant in C57BI/6 syn- ergistical mice was decreased significantly after implanted with EL-4/IL-12 transfectant compaired with EL-4/Wt or EL-4/Neo groups (P
