Comparison of Antitumor Effect in vivo between Transmembrane TNF-? and Secretory TNF-?
- VernacularTitle:比较跨膜型与分泌型TNF-?在体内的杀瘤效应
- Author:
Qingfen LI
;
Wei FENG
;
Zhuoya LI
;
Feili GONG
;
Xiaodan JIANG
;
Long XU
;
Pin XIONG
- Publication Type:Journal Article
- Keywords:
gene therapy: TM-TNF-a;
S-TNF-a;
direct injection of DNA;
antitumor effect
- From:
Chinese Journal of Cancer Biotherapy
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the antitumor effects of transmembrane TNF-? and secretory TNF-? in vivo. Methods: Three types of TNF-? cDNA plasmids (wild type TNF-?; transmembrane TNF-? mutant; secretory TNF-? mutant) were directly injected into tumor-tearing mice. Results: The three types of TNF-? could be expressed by tumor cells and all of them could inhibit evidently the rate of tumor growth. The tumor regression after treatment with transmembrane TNF-? mutant at the early stage was more significant than that with the other two types of TNF-?( P
