Inhibitory Efficiency on Growth in vivo of B16 Melanoma Cell Expressing Angiostatin
- VernacularTitle:表达Angiostatin基因的B16黑色素瘤体内抑制作用
- Author:
Guohong XIA
;
Weixin LU
;
Li XING
;
Jian FEI
;
Lihe GUO
- Publication Type:Journal Article
- Keywords:
B16 melanoma;
angiostatin;
gene expression;
angiogenesis
- From:
Chinese Journal of Cancer Biotherapy
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Study on the growth character of B16 melanoma cell which can express angiostatin. Methods: Angiostatin gene was constructed from human plasminogen cDNA by deletion mutation. A B16 melanoma cell clone named BAG28 which stably expresses angiostatin was established by introducing gene into it. Results: BAG28 in vitro had no changes in proliferation rate and the ability of clone formation in soft agar. Study in vitro showed that the tumor weight had reduced about 87% ( P
