EFFECT OF CHITOSAN ON DELAYED OUTWARD POTASSIUM CURRENT IN SINGLE VENTRICULAR MYOCYTES OF GUINEA PIG
- VernacularTitle:壳聚糖对豚鼠单一心室肌细胞延迟外向钾电流的作用
- Author:
Jinming LI
;
Shenli ZHANG
;
Qinghuan XIAO
;
Yuping WANG
;
Keyi ZHANG
- Publication Type:Journal Article
- Keywords:
Chitosan;
Patch clamp technique;
IK;
single ventricular myocyte
- From:
Chinese Journal of Marine Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the effect of chitosan on delayed outward potassium current(IK) in single ventricular myocytes of guinea pig and investigate its antiarrhythmic mechanism from ion channel view. Patch clamp technique with whole-cell configuration. Holding potential was -40mV,commanding potential was -60- + 70mV ,step pulse +10mV,stimulating frequency 1 Hz,duration 300 ms and stimulating interval 6s. The result showed that Chitosan inhibited IK in a dose -dependent manner. Conclusion :Chitosan can inhibite IK in single ventricular myocytes of guinea pig.
