The Role of Membrane TNF-a in Murine Con A-LAK Cell Mediated MHC Non-restricted Tumoricidal Effect
- VernacularTitle:膜TNF-?在小鼠Con A-LAK细胞介导的MHC非限制性杀瘤效应中的作用
- Author:
Yali ZHAO
;
Guangxia SHI
;
Lianyin GUO
- Publication Type:Journal Article
- Keywords:
Con A-LAK cell;
MHC non-restricted tumoricidal effect;
mTNF-a
- From:
Chinese Journal of Cancer Biotherapy
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
This essay investigated the in vitro tumoricidal activity of Con A primed murine LAK cells (Con A-LAK), discussed the role of mTNF-? in the killing effect. The results showed that Con A-LAK cells could kill NK sensitive YAC-1, TNF sensitive L929 and H-2 low/non expression HCa-F target cells; The cytotoxicitity of Con A-LAK cells was performed by direct contact, the non-secretary pathway mediated by interaction of surface ligands of effector cells and receptors of target cells play an important role; Con A-LAK cells expressed mTNF-?, which participated in the killing of TNF sensitive tumor cells and might be one of the important effector molecules in MHC non-restricted, antigen non-specific cvtotoxicitv.
