STUDIES ON THE ANTINEOPLASTIC CONSTITUENTS FROM MARINE BRYOZOAN BUGULA NERITINA IN THE SOUTH CHINA SEA( I )
- VernacularTitle:中国南海总合草苔虫中抗肿瘤活性成分研究——Ⅰ.Bryostatin 4～6的分离鉴定及其体外抗肿瘤活性
- Author:
Houwen LIN
;
Xinsheng YAO
;
Yanghua YI
- Publication Type:Journal Article
- Keywords:
Bugula neritina;
antineoplastic activities;
bryostatins
- From:
Chinese Journal of Marine Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Three active compounds were isolated from the marine bryozoan Bugula neritina living in the South China Sea by bioassay-guiding isolation method with a combination of extraction with suitable solvent and multiple column chromatography(Sephadex LH-20, ODS and preparative HPLC). Their structures were assigned as known bryostatin 4, bryostatin 5 and bryostatin 6 by intensive analysis of the data of high resolution 2DNMR(600 MHz,DQF-COSY,TOCSY,HMQC and ROESY). All these compounds were obtained from this bryozoan in the South China Sea for the first time and showed significant antineoplastic activities in vitro.
